Institute of Medical Psychology and Behavioral Immunobiology
+49 201 723 4501

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Professor Dr. rer. biol. hum. Manfred Schedlowski

 

Tel. +49 201 723 4500 oder 4501

 

 

Curriculum

Manfred Schedlowski is Professor and Director of the Institute of Medical Psychology and Behavioral Immunobiology at the Medical Faculty, University of Duisburg-Essen, Germany. Born in Hannover, Germany, he obtained his degree in Psychology and his PhD at the Department of Medical Psychology, Hannover Medical School, Germany. Since October 1997, Manfred Schedlowski is Full Professor and Director of the Institute of Medical Psychology and Behavioral Immunobiology at the Medical Faculty, University Essen-Duisburg, interrupted by a research stay as Professor of Psychology and Behavioral Immunobiology at the Swiss Federal Institute of Technology (ETH) in Zürich, Switzerland (2004-2007).

Interests

My current primary focus of research is the neurobiology of placebo and nocebo responses, in particular the mechanisms and clinical relevance of behavioral or Pavlovian conditioning of immune functions. In addition, we analyze how functions of the peripheral immune system affect mood and emotional processes as well as neuropsychological functions such as learning and memory and how these processes contribute to the pathophysiology of neuropsychiatric diseases such as depression and schizophrenia.

Research projects

Placebo effects in the immune functions: The role of learning processes and conditioning
Funding DFG: SCHE 341/13-1, SCHE 341/17-1-2, SCHE 341/19-1-2
Inflammation, sickness behavior and depression
IFORES research grant
Animal models of neuropsychiatric disorders
Funding DFG:EN 814/2-1 and DAAD
Neuroendocrine regulation of immune responses
Effects of immune-modulating drugs on brain and behavior

Selected publications

Engler H, Brendt P, Wischermann J, Wegner A, Röhling R, Schoemberg T, Meyer U, Gold R, Peters J, Benson S, Schedlowski M.
Selective increase of cerebrospinal fluid IL-6 during experimental systemic inflammation in humans: association with depressive symptoms.
Mol Psychiatry. 2017;22:1448-1454.

Hadamitzky M, Bösche K, Wirth T, Buck B, Beetz O, Christians U, Schniedewind B, Lückemann L, Güntürkün O, Engler H, Schedlowski M.
Memory-updating abrogates extinction of learned immunosuppression.
Brain Behav Immun. 2016;52:40-8.

Schedlowski M, Enck P, Rief W, Bingel U.
Neuro-Bio-Behavioral Mechanisms of Placebo and Nocebo Responses: Implications for Clinical Trials and Clinical Practice
Pharmacol Rev. 2015; 697-730

Albring A, Wendt L, Benson S, Nissen S, Yavuz Z, Engler H, Witzke O, Schedlowski M.
Preserving learned immunosuppressive placebo response: Perspectives for clinical application.
Clin Pharmacol Ther. 2014;96:247-55.

Schedlowski M, Engler H, Grigoleit JS.
Endotoxin-induced experimental systemic inflammation in humans: a model to disentangle immune-to-brain communication.
Brain Behav Immun. 2014;35:1-8.

Giovanoli S, Engler H, Engler A, Richetto J, Voget M, Willi R, Winter C, Riva MA, MortensenPB, Schedlowski M, Meyer U.
Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice.
Science. 2013;339:1095-9.

Enck P, Bingel U, Schedlowski M, Rief W.
The placebo reponse in medicine: minimize, maximize or personalize.
Nat Rev Drug Discov. 2013;12:191-204.