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Head of department
Prof. Dr.


Curriculum Vitae

Manfred Schedlowski is Professor and Director of the Institute of Medical Psychology and Behavioral Immunobiology at the Medical Faculty, University of Duisburg-Essen, Germany. Born 1957 in Hannover, Germany, he obtained his degree in Psychology and his PhD at the Department of Medical Psychology, Hannover Medical School, Germany. Since October 1997, Manfred Schedlowski is Full Professor and Director of the Institute of Medical Psychology and Behavioral Immunobiology at the Medical Faculty, University Essen-Duisburg interrupted by a research stay as Professor of Psychology and Behavioral Immunobiology at the Swiss Federal Institute of Technology (ETH) in Zürich, Switzerland (2004-2007).


Manfred Schedlowski’s current primary focus of research is the neurobiology of placebo and nocebo responses, in particular the mechanisms and clinical relevance of behavioral or Pavlovian conditioning of immune and neuroendocrine functions. In addition, he is analyzing the effects of peripheral inflammatory processes on neurocognitive and affective functions and the relevance of these effects for the development and maintenance of neuropsychiatric diseases such as depression or schizophrenia.

Selected publications

Flasbeck V, Dersch N, Engler H, Schedlowski M, Brüne (2024). Acute experimental inflammation in healthy women attenuates empathy for psychological pain. M.Brain Behav Immun. 119:1-5. doi: 10.1016/j.bbi.2024.03.032. Online ahead of print.

Basedow LA, Fischer A, Benson S, Bingel U, Brassen S, Büchel C, Engler H, Mueller EM, Schedlowski M, Rief W (2023). The influence of psychological traits and prior experience on treatment expectations. Compr Psychiatry. 127:152431.

Hetze S, Barthel L, Lückemann L, Günther HS, Wülfing C, Salem Y, Jakobs M, Hörbelt-Grünheidt T, Petschulat J, Bendix I, Weber-Stadlbauer U, Sure U, Schedlowski M, Hadamitzky M (2022). Taste-immune associative learning amplifies immunopharmacological effects and attenuates disease progression in a rat glioblastoma model. Brain Behav Immun. 106:270-279.

Hadamitzky M, Schedlowski M (2022). Harnessing associative learning paradigms to optimize drug treatment. Trends Pharmacol Sci. 464-472.

Lückemann L, Hetze S, Hörbelt T, Jakobs M, Schedlowski M, Hadamitzky M (2021). Incomplete reminder cues trigger memory reconsolidation and sustain learned immune responses. Brain Behav Immun. 95: 115-121.

Lasselin J, Lekander M, Benson S, Schedlowski M, Engler H (2020). Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression. Mol Psychiatry. 26: 3672-3683.

Lückemann L, Stangl H, Straub RH, Schedlowski M, Hadamitzky M (2020). Learned immunosuppressive placebo response attenuates disease progression in a rodent model of rheumatoid arthritis. Arthritis Rheumatol. 72: 588-597.

Hadamitzky M, Lückemann L, Pacheco-López G, Schedlowski M (2020). Behaviorally Conditioned Responses in Immunological and Neuroendocrine Functions. Physiol Rev. 100: 357-405.

Kirchhof J, Petrakova L, Brinkhoff A, Benson S, Schmidt J, Unteroberdörster M, Wilde B, Kaptchuk TJ, Witzke O, Schedlowski M (2018). Learned immunosuppressive placebo responses in renal transplant patients. Proc Natl Acad Sci. 115: 4223-4227.

Engler H, Brendt P, Wischermann J, Wegner A, Röhling R, Schoemberg T, Meyer U, Gold R, Peters J, Benson S, Schedlowski M (2017). Selective increase of cerebrospinal fluid IL-6 during experimental systemic inflammation in humans: association with depressive symptoms. Mol Psychiatry. 2017;22: 1448-1454.

Hadamitzky M, Bösche K, Wirth T, Buck B, Beetz O, Christians U, Schniedewind B, Lückemann L, Güntürkün O, Engler H, Schedlowski M (2016). Memory-updating abrogates extinction of learned immunosuppression. Brain Behav Immun. 52: 40-8.

Schedlowski M, Enck P, Rief W, Bingel U (2015). Neuro-Bio-Behavioral Mechanisms of Placebo and Nocebo Responses: Implications for Clinical Trials and Clinical Practice. Pharmacol Rev. 697-730.

Albring A, Wendt L, Benson S, Nissen S, Yavuz Z, Engler H, Witzke O, Schedlowski M (2014). Preserving learned immunosuppressive placebo response: Perspectives for clinical application. Clin Pharmacol Ther. 96: 247-55.

Schedlowski M, Engler H, Grigoleit JS (2014). Endotoxin-induced experimental systemic inflammation in humans: a model to disentangle immune-to-brain communication. Brain Behav Immun. 35: 1-8.

Giovanoli S, Engler H, Engler A, Richetto J, Voget M, Willi R, Winter C, Riva MA, MortensenPB, Schedlowski M, Meyer U (2013). Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice. Science. 339: 1095-9.

Enck P, Bingel U, Schedlowski M, Rief W (2013). The placebo reponse in medicine: minimize, maximize or personalize. Nat Rev Drug Discov. 12: 191-204.

About us

The Institute of Medical Psychology was founded in 1978 and is one of the pre-clinical Departments of the Essen University Hospital.


  • Institute of Medical Psychology and Behavioral Immunobiology
    University Hospital Essen
    Hufelandstr. 55
    45122 Essen